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Just One Position-Independent Lysine Residue Can Direct MelanA into Proteasomal Degradation following N-Terminal Fusion of Ubiquitin

N-terminal stable in frame fusion of ubiquitin (Ub) has been shown to target the fusion protein for proteasomal degradation. This pathway, called the Ub fusion degradation (UFD), might also elevate MHC class I (MHC-I) antigen presentation of specific antigens. The UFD, mainly studied on cytosolic pr...

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書誌詳細
主要な著者: Setz, Christian, Friedrich, Melanie, Hahn, Sabine, Dörrie, Jan, Schaft, Niels, Schuler, Gerold, Schubert, Ulrich
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564756/
https://ncbi.nlm.nih.gov/pubmed/23393593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055567
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