Just One Position-Independent Lysine Residue Can Direct MelanA into Proteasomal Degradation following N-Terminal Fusion of Ubiquitin

N-terminal stable in frame fusion of ubiquitin (Ub) has been shown to target the fusion protein for proteasomal degradation. This pathway, called the Ub fusion degradation (UFD), might also elevate MHC class I (MHC-I) antigen presentation of specific antigens. The UFD, mainly studied on cytosolic pr...

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Autors principals: Setz, Christian, Friedrich, Melanie, Hahn, Sabine, Dörrie, Jan, Schaft, Niels, Schuler, Gerold, Schubert, Ulrich
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564756/
https://ncbi.nlm.nih.gov/pubmed/23393593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055567
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