Just One Position-Independent Lysine Residue Can Direct MelanA into Proteasomal Degradation following N-Terminal Fusion of Ubiquitin

N-terminal stable in frame fusion of ubiquitin (Ub) has been shown to target the fusion protein for proteasomal degradation. This pathway, called the Ub fusion degradation (UFD), might also elevate MHC class I (MHC-I) antigen presentation of specific antigens. The UFD, mainly studied on cytosolic pr...

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Bibliografiske detaljer
Main Authors: Setz, Christian, Friedrich, Melanie, Hahn, Sabine, Dörrie, Jan, Schaft, Niels, Schuler, Gerold, Schubert, Ulrich
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564756/
https://ncbi.nlm.nih.gov/pubmed/23393593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055567
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