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Protein quality control in the ER: balancing the ubiquitin chequebook
Protein maturation in the endoplasmic reticulum (ER) is subject to stringent quality control. Terminally misfolded polypeptides are usually ejected into the cytoplasm and targeted for destruction by the proteasome. Ubiquitin conjugation is essential for both extraction and proteolysis. Here, we disc...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3564647/ https://ncbi.nlm.nih.gov/pubmed/22055166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2011.09.010 |
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