Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis

Mice lacking Junctional Adhesion Molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colitis. To investigate the contribution of adaptive immune compensation in response to incre...

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Detalhes bibliográficos
Main Authors: Khounlotham, Manirath, Kim, Wooki, Peatman, Eric, Nava, Porfirio, Medina-Contreras, Oscar, Addis, Caroline, Koch, Stefan, Fournier, Benedicte, Nusrat, Asma, Denning, Timothy L., Parkos, Charles A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564580/
https://ncbi.nlm.nih.gov/pubmed/22981539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.06.017
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