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The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair

BACKGROUND & AIMS: Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue damage by promoting apoptosis of epithelial cells. However, little is known about the physiologic role of Dkk1 in normal intestin...

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Détails bibliographiques
Auteurs principaux: KOCH, STEFAN, NAVA, PORFIRIO, ADDIS, CAROLINE, KIM, WOOKI, DENNING, TIMOTHY L., LI, LINHENG, PARKOS, CHARLES A., NUSRAT, ASMA
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551610/
https://ncbi.nlm.nih.gov/pubmed/21440550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.03.043
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