The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment

We obtained detailed kinetic characteristics–stoichiometry, reaction rates, substrate affinities and equilibrium conditions–of human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). This enzyme synthesizes ‘high-energy’ PP-InsPs (diphosphoinositol polyphosphates) by metabolizing InsP(6) (inos...

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Bibliographic Details
Main Authors: Weaver, Jeremy D., Wang, Huanchen, Shears, Stephen B.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2013
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564036/
https://ncbi.nlm.nih.gov/pubmed/23240582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120115
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