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Amyloid-beta Oligomerization in Alzheimer Dementia vs. High Pathology Controls

OBJECTIVE: While amyloid-beta (Aβ) peptide deposition into insoluble plaques is a pathological hallmark of Alzheimer’s disease, soluble oligomeric Aβ has been hypothesized to more directly underlie impaired learning and memory in dementia of the Alzheimer type. However, the lack of a sensitive, spec...

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Autors principals: Esparza, Thomas J., Zhao, Hanzhi, Cirrito, John R., Cairns, Nigel J., Bateman, Randall J., Holtzman, David M., Brody, David L.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563737/
https://ncbi.nlm.nih.gov/pubmed/23225543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23748
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