Inhibition of Myelin-Cleaving Poteolytic Activities by Interferon-Beta in Rat Astrocyte Cultures. Comparative Analysis between Gelatinases and Calpain-II

BACKGROUND: Proteolytic enzymes have been implicated in the pathogenesis of Multiple Sclerosis (MS) for both their ability to degrade myelin proteins and for their presence in MS plaques.In this study we investigated whether interferon-beta (IFN-β) could differently modulate the activity and the exp...

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Bibliographic Details
Main Authors: Latronico, Tiziana, Branà, Maria Teresa, Gramegna, Pasqua, Fasano, Anna, Di Bari, Gaetano, Liuzzi, Grazia Maria
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563665/
https://ncbi.nlm.nih.gov/pubmed/23390485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049656
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