Inhibition of Myelin-Cleaving Poteolytic Activities by Interferon-Beta in Rat Astrocyte Cultures. Comparative Analysis between Gelatinases and Calpain-II

BACKGROUND: Proteolytic enzymes have been implicated in the pathogenesis of Multiple Sclerosis (MS) for both their ability to degrade myelin proteins and for their presence in MS plaques.In this study we investigated whether interferon-beta (IFN-β) could differently modulate the activity and the exp...

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Autors principals: Latronico, Tiziana, Branà, Maria Teresa, Gramegna, Pasqua, Fasano, Anna, Di Bari, Gaetano, Liuzzi, Grazia Maria
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563665/
https://ncbi.nlm.nih.gov/pubmed/23390485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049656
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