Tacrolimus Enhances the Potency of Posaconazole Against Rhizopus oryzae In Vitro and in an Experimental Model of Mucormycosis

Background. We hypothesized that tacrolimus, an inhibitor of the calcineurin pathway, would enhance the in vivo activity of posaconazole against Rhizopus oryzae, the Mucorales species most commonly associated with mucormycosis. Methods. We examined patterns of growth inhibition and fungicidal activi...

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Detaylı Bibliyografya
Asıl Yazarlar: Lewis, Russell E., Ben-Ami, Ronen, Best, Leyla, Albert, Nathaniel, Walsh, Thomas J., Kontoyiannis, Dimitrios P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2013
Konular:
Major Articles and Brief Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563310/
https://ncbi.nlm.nih.gov/pubmed/23242544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis767
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