Methodology of a large prospective, randomised, open, blinded endpoint streamlined safety study of celecoxib versus traditional non-steroidal anti-inflammatory drugs in patients with osteoarthritis or rheumatoid arthritis: protocol of the standard care versus celecoxib outcome trial (SCOT)

INTRODUCTION: Cyclooxygenase 2 (COX-2) inhibitors have less upper gastrointestinal toxicity than traditional non-steroidal anti-inflammatory drugs (NSAIDs). However, both COX-2 inhibitors and traditional NSAIDs may be associated with adverse cardiovascular side effects. Data from randomised and obse...

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Hlavní autoři: MacDonald, Thomas M, Mackenzie, Isla S, Wei, Li, Hawkey, Christopher J, Ford, Ian
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2013
Témata:
Pharmacology and Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563118/
https://ncbi.nlm.nih.gov/pubmed/23364320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjopen-2012-002295
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