Epidermal Growth Factor Receptor Mutation Status and Rad51 Determine the Response of Glioblastoma to Multimodality Therapy with Cetuximab, Temozolomide, and Radiation

Purpose: EGFR amplification and mutation (i.e., EGFRvIII) are found in 40% of primary GBM tumors and are believed to contribute to tumor development and therapeutic resistance. This study was designed to investigate how EGFR mutational status modulates response to multimodality treatment with cetuxi...

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Detalhes bibliográficos
Main Authors: Wachsberger, Phyllis Rachelle, Lawrence, Richard Yaacov, Liu, Yi, Rice, Barbara, Daskalakis, Constantine, Dicker, Adam P.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563086/
https://ncbi.nlm.nih.gov/pubmed/23383403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00013
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