N(6)-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression

Glioblastoma is among the most common malignant brain tumors and has a dismal prognosis due to the poor response to therapeutic regimens such as ionizing radiation and DNA-alkylating agents. In our study, we investigated the radiosensitizing activity of the N(6)-isopentenyladenosine (iPA), an natura...

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Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Navarra, Giovanna, Pagano, Cristina, Pacelli, Roberto, Crescenzi, Elvira, Longobardi, Elena, Gazzerro, Patrizia, Fiore, Donatella, Pastorino, Olga, Pentimalli, Francesca, Laezza, Chiara, Bifulco, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971108/
https://ncbi.nlm.nih.gov/pubmed/31993371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01498
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