FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA Repair Gene Rad51

PURPOSE: Recurrent glioblastoma multiforme (GBM) is characterized by resistance to radiotherapy and chemotherapy and a poor clinical prognosis. In this study, we investigated the role of the oncogenic transcription factor FoxM1 in GBM cells’ resistance to TMZ and its potential molecular mechanism. E...

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Bibliographic Details
Main Authors: Zhang, Nu, Wu, Xinjian, Yang, Lixuan, Xiao, Feizhe, Zhang, Heng, Zhou, Aidong, Huang, Zhengsong, Huang, Suyun
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639123/
https://ncbi.nlm.nih.gov/pubmed/22977194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-0039
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