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High-pressure NMR reveals close similarity between cold and alcohol protein denaturation in ubiquitin

Proteins denature not only at high, but also at low temperature as well as high pressure. These denatured states are not easily accessible for experiment, because usually heat denaturation causes aggregation, whereas cold or pressure denaturation occurs at temperatures well below the freezing point...

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Autori principali: Vajpai, Navratna, Nisius, Lydia, Wiktor, Maciej, Grzesiek, Stephan
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562818/
https://ncbi.nlm.nih.gov/pubmed/23284170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212222110
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