A binding site for non-steroidal anti-inflammatory drugs in FAAH

In addition to inhibiting the cyclooxygenasemediated biosynthesis of prostanoids, various widely used non-steroidal anti-inflammatory drugs (NSAIDs) enhance endocannabinoid signaling by blocking the anandamidedegrading membrane enzyme, fatty acid amide hydrolase (FAAH). The X-ray structure of FAAH i...

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Main Authors: Bertolacci, Laura, Romeo, Elisa, Veronesi, Marina, Magotti, Paola, Albani, Clara, Dionisi, Mauro, Lambruschini, Chiara, Scarpelli, Rita, Cavalli, Andrea, Vivo, Marco De, Piomelli, Daniele, Garau, Gianpiero
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562592/
https://ncbi.nlm.nih.gov/pubmed/23240907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja308733u
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