Expression of M. tuberculosis-induced suppressor of cytokine signaling (SOCS) 1, SOCS3, FoxP3 and secretion of IL-6 associates with differing clinical severity of tuberculosis

BACKGROUND: Appropriate immune activation of T cells and macrophages is central for the control of Mycobacterium tuberculosis infections. IFN-γ stimulated responses are lowered in tuberculosis (TB), while expression of Suppressor of Cytokine Signaling (SOCS) molecules – 1 and 3 and CD4(+)CD25(+)FoxP...

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Main Authors: Masood, Kiran I, Rottenberg, Martin E, Salahuddin, Naseem, Irfan, Muhammad, Rao, Nisar, Carow, Berit, Islam, Muniba, Hussain, Rabia, Hasan, Zahra
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562147/
https://ncbi.nlm.nih.gov/pubmed/23320781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-13-13
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