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Deregulation of poly(A) polymerase I in Escherichia coli inhibits protein synthesis and leads to cell death
Polyadenylation plays important roles in RNA metabolism in both prokaryotes and eukaryotes. Surprisingly, deregulation of polyadenylation by poly(A) polymerase I (PAP I) in Escherichia coli leads to toxicity and cell death. We show here that mature tRNAs, which are normally not substrates for PAP I...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561954/ https://ncbi.nlm.nih.gov/pubmed/23241393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1280 |
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