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Deregulation of poly(A) polymerase I in Escherichia coli inhibits protein synthesis and leads to cell death

Polyadenylation plays important roles in RNA metabolism in both prokaryotes and eukaryotes. Surprisingly, deregulation of polyadenylation by poly(A) polymerase I (PAP I) in Escherichia coli leads to toxicity and cell death. We show here that mature tRNAs, which are normally not substrates for PAP I...

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Autori principali: Mohanty, Bijoy K., Kushner, Sidney R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561954/
https://ncbi.nlm.nih.gov/pubmed/23241393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks1280
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