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Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance
Mammalian mitochondrial DNA (mtDNA) is replicated by the heterotrimeric Pol γ comprised of a single catalytic subunit, encoded by Polg, and a homodimeric accessory subunit encoded by the Polg2 gene. While the catalytic subunit has been shown to be essential for embryo development, genetic data regar...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561914/ https://ncbi.nlm.nih.gov/pubmed/23197651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds506 |
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