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Stereoselective Access to Z- and E-Macrocycles by Ruthenium- Catalyzed Z-Selective Ring-Closing Metathesis and Ethenolysis

The first report of Z-selective macrocyclizations using a ruthenium-based metathesis catalyst is described. Selectivity for Z-macrocycles is consistently high for a diverse set of substrates with a variety of functional groups and ring sizes. The same catalyst was also employed for the Z-selective e...

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Autors principals: Marx, Vanessa M., Herbert, Myles B., Keitz, Benjamin K., Grubbs, Robert H.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561906/
https://ncbi.nlm.nih.gov/pubmed/23244210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja311241q
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