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Stereoselective synthesis of macrocyclic peptides via a dual olefin metathesis and ethenolysis approach

Macrocyclic compounds occupy an important chemical space between small molecules and biologics and are prevalent in many natural products and pharmaceuticals. The growing interest in macrocycles has been fueled, in part, by the design of novel synthetic methods to these compounds. One appealing stra...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Mangold, Shane L., Grubbs, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618480/
https://ncbi.nlm.nih.gov/pubmed/26509000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01507c
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