Mechanism and function of Vav1 localisation in TCR signalling

The antigen-specific binding of T cells to antigen presenting cells results in recruitment of signalling proteins to microclusters at the cell-cell interface known as the immunological synapse (IS). The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) si...

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Detalhes bibliográficos
Main Authors: Ksionda, Olga, Saveliev, Alexander, Köchl, Robert, Rapley, Jonathan, Faroudi, Mustapha, Smith-Garvin, Jennifer E., Wülfing, Christoph, Rittinger, Katrin, Carter, Tom, Tybulewicz, Victor L. J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561853/
https://ncbi.nlm.nih.gov/pubmed/22956543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.105148
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