Upon Wnt stimulation, Rac1 activation requires Rac1 and Vav2 binding to p120-catenin

A role for Rac1 GTPase in canonical Wnt signaling has recently been demonstrated, showing that it is required for β-catenin translocation to the nucleus. In this study, we investigated the mechanism of Rac1 stimulation by Wnt. Upregulation of Rac1 activity by Wnt3a temporally correlated with enhance...

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Main Authors: Valls, Gabriela, Codina, Montserrat, Miller, Rachel K., Del Valle-Pérez, Beatriz, Vinyoles, Meritxell, Caelles, Carme, McCrea, Pierre D., de Herreros, Antonio García, Duñach, Mireia
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561852/
https://ncbi.nlm.nih.gov/pubmed/22946057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.101030
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