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Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation

During sepsis, acute lung injury (ALI) results from activation of innate immune cells and endothelial cells by endotoxins, leading to systemic inflammation through proinflammatory cytokine overproduction, oxidative stress, and intracellular Ca(2+) overload. Despite considerable investigation, the un...

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Detalhes bibliográficos
Main Authors: Gandhirajan, Rajesh Kumar, Meng, Shu, Chandramoorthy, Harish C., Mallilankaraman, Karthik, Mancarella, Salvatore, Gao, Hui, Razmpour, Roshanak, Yang, Xiao-Feng, Houser, Steven R., Chen, Ju, Koch, Walter J., Wang, Hong, Soboloff, Jonathan, Gill, Donald L., Madesh, Muniswamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561818/
https://ncbi.nlm.nih.gov/pubmed/23348743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65647
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