Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation

During sepsis, acute lung injury (ALI) results from activation of innate immune cells and endothelial cells by endotoxins, leading to systemic inflammation through proinflammatory cytokine overproduction, oxidative stress, and intracellular Ca(2+) overload. Despite considerable investigation, the un...

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Bibliografski detalji
Glavni autori: Gandhirajan, Rajesh Kumar, Meng, Shu, Chandramoorthy, Harish C., Mallilankaraman, Karthik, Mancarella, Salvatore, Gao, Hui, Razmpour, Roshanak, Yang, Xiao-Feng, Houser, Steven R., Chen, Ju, Koch, Walter J., Wang, Hong, Soboloff, Jonathan, Gill, Donald L., Madesh, Muniswamy
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561818/
https://ncbi.nlm.nih.gov/pubmed/23348743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65647
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