Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice

Klotho is a potent regulator of 1,25-hydroxyvitamin D3 [1,25(OH)(2)D(3)] formation and calcium-phosphate metabolism. Klotho-hypomorphic mice (kl/kl mice) suffer from severe growth deficits, rapid aging, hyperphosphatemia, hyperaldosteronism, and extensive vascular and soft tissue calcification. Sequ...

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Main Authors: Voelkl, Jakob, Alesutan, Ioana, Leibrock, Christina B., Quintanilla-Martinez, Leticia, Kuhn, Volker, Feger, Martina, Mia, Sobuj, Ahmed, Mohamed S.E., Rosenblatt, Kevin P., Kuro-o, Makoto, Lang, Florian
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561808/
https://ncbi.nlm.nih.gov/pubmed/23298834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64093
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