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1,25(OH)(2)D(3) dependent overt hyperactivity phenotype in klotho-hypomorphic mice
Klotho, a protein mainly expressed in kidney and cerebral choroid plexus, is a powerful regulator of 1,25(OH)(2)D(3) formation. Klotho-deficient mice (kl/kl) suffer from excessive plasma 1,25(OH)(2)D(3)-, Ca(2+)- and phosphate-concentrations, leading to severe soft tissue calcification and accelerat...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4843009/ https://ncbi.nlm.nih.gov/pubmed/27109615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24879 |
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