Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice

Congenital biliary atresia is an incurable disease of newborn infants, of unknown genetic causes, that results in congenital deformation of the gallbladder and biliary duct system. Here, we show that during mouse organogenesis, insufficient SOX17 expression in the gallbladder and bile duct epithelia...

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Detalhes bibliográficos
Main Authors: Uemura, Mami, Ozawa, Aisa, Nagata, Takumi, Kurasawa, Kaoruko, Tsunekawa, Naoki, Nobuhisa, Ikuo, Taga, Tetsuya, Hara, Kenshiro, Kudo, Akihiko, Kawakami, Hayato, Saijoh, Yukio, Kurohmaru, Masamichi, Kanai-Azuma, Masami, Kanai, Yoshiakira
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561787/
https://ncbi.nlm.nih.gov/pubmed/23293295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.086702
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