Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia

The gallbladder excretes cytotoxic bile acids into the duodenum through the cystic duct and common bile duct system. Sox17 haploinsufficiency causes biliary atresia-like phenotypes and hepatitis in late organogenesis mouse embryos, but the molecular and cellular mechanisms underlying this remain unc...

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Bibliographic Details
Published in:Development
Main Authors: Higashiyama, Hiroki, Ozawa, Aisa, Sumitomo, Hiroyuki, Uemura, Mami, Fujino, Ko, Igarashi, Hitomi, Imaimatsu, Kenya, Tsunekawa, Naoki, Hirate, Yoshikazu, Kurohmaru, Masamichi, Saijoh, Yukio, Kanai-Azuma, Masami, Kanai, Yoshiakira
Format: Artigo
Language:Inglês
Published: The Company of Biologists Ltd 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5450840/
https://ncbi.nlm.nih.gov/pubmed/28432216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.147512
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