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A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster

In mammalian cells, hydrogen peroxide (H(2)O(2))-induced adaptation to oxidative stress is strongly dependent on an Nrf2 transcription factor-mediated increase in the 20S proteasome. Here, we report that both Caenorhabditis elegans nematode worms and Drosophila melanogaster fruit flies are also capa...

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Detalhes bibliográficos
Main Authors: Pickering, Andrew M., Staab, Trisha A., Tower, John, Sieburth, Derek, Davies, Kelvin J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561776/
https://ncbi.nlm.nih.gov/pubmed/23038734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jeb.074757
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