The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster

Hallmarks of aging include loss of protein homeostasis and dysregulation of stress-adaptive pathways. Loss of adaptive homeostasis, increases accumulation of DNA, protein, and lipid damage. During acute stress, the Cnc-C (Drosophila Nrf2 orthologue) transcriptionally-regulated 20S proteasome degrade...

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Publicado en:Aging (Albany NY)
Autores principales: Pomatto, Laura C.D., Wong, Sarah, Carney, Caroline, Shen, Brenda, Tower, John, Davies, Kelvin J. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425120/
https://ncbi.nlm.nih.gov/pubmed/28373600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101218
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