Thrombin-cleaved Fragments of Osteopontin Are Overexpressed in Malignant Glial Tumors and Provide a Molecular Niche with Survival Advantage

Osteopontin (OPN), which is highly expressed in malignant glioblastoma (GBM), possesses inflammatory activity modulated by proteolytic cleavage by thrombin and plasma carboxypeptidase B2 (CPB2) at a highly conserved cleavage site. Full-length OPN (OPN-FL) was elevated in cerebrospinal fluid (CSF) sa...

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Autors principals: Yamaguchi, Yasuto, Shao, Zhifei, Sharif, Shadi, Du, Xiao-Yan, Myles, Timothy, Merchant, Milton, Harsh, Griffith, Glantz, Michael, Recht, Lawrence, Morser, John, Leung, Lawrence L. K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561533/
https://ncbi.nlm.nih.gov/pubmed/23204518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.362954
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