Thrombin-activatable carboxypeptidase B-cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis

OBJECTIVE: Osteopontin (OPN) is a pro-inflammatory cytokine important in rheumatoid arthritis (RA). OPN can be cleaved by thrombin, leading to OPN-Arg (OPN-R) and exposing the cryptic C-terminal α(4)β(1) and α(9)β(1) integrin-binding motif (SVVYGLR). Thrombin-activatable carboxypeptidase B (CPB), al...

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Main Authors: Sharif, Shadi A., Du, Xiaoyan, Myles, Timothy, Song, Jason J., Price, Elizabeth, Lee, David M., Goodman, Stuart B., Nagashima, Mariko, Morser, John, Robinson, William H., Leung, Lawrence L.K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3757557/
https://ncbi.nlm.nih.gov/pubmed/19790060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24814
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