P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor β Expression and Enhanced Matrix Metalloproteinase 9 Secretion

P21-activated kinases (Paks) are major effectors downstream of the small Rho family of GTPases. Among the six isoforms, Pak1 is the most ubiquitous and the best characterized member. Previous studies have shown that inhibition of Pak6, which is predominantly present in the prostate compared with oth...

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Detalhes bibliográficos
Main Authors: Goc, Anna, Al-Azayzih, Ahmad, Abdalla, Maha, Al-Husein, Belal, Kavuri, Sravankumar, Lee, Jeffrey, Moses, Kelvin, Somanath, Payaningal R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561527/
https://ncbi.nlm.nih.gov/pubmed/23258534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424770
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