SUMO-1 Modification on K166 of PolyQ-Expanded aTaxin-3 Strengthens Its Stability and Increases Its Cytotoxicity

Post-translational modification by SUMO was proposed to modulate the pathogenesis of several neurodegenerative diseases. Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disease caused by polyQ-expanded ataxin-3. We have previously shown that...

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Hlavní autoři: Zhou, Ya-Fang, Liao, Shu-Sheng, Luo, Ying-Ying, Tang, Jian-Guang, Wang, Jun-Ling, Lei, Li-Fang, Chi, Jing-Wei, Du, Juan, Jiang, Hong, Xia, Kun, Tang, Bei-Sha, Shen, Lu
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561348/
https://ncbi.nlm.nih.gov/pubmed/23382880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054214
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