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Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis
Rnf8 is an E3 ubiquitin ligase that plays a key role in the DNA damage response as well as in the maintenance of telomeres and chromatin remodeling. Rnf8(−/−) mice exhibit developmental defects and increased susceptibility to tumorigenesis. We observed that levels of p53, a central regulator of the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561120/ https://ncbi.nlm.nih.gov/pubmed/23382699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003259 |
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