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Effect of Rifampicin on S-ketamine and S-norketamine Plasma Concentrations in Healthy Volunteers after Intravenous S-ketamine Administration

BACKGROUND: Low-dose ketamine is used as analgesic for acute and chronic pain. It is metabolized in the liver to norketamine via cytochrome P450 enzymes. There are few human data on the involvement of CYP enzymes on the elimination of norketamine and its possible contribution to analgesic effect. Th...

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Autores principales: Noppers, Ingeborg, Olofsen, Erik, Niesters, Marieke, Aarts, Leon, Mooren, René, Dahan, Albert, Kharasch, Evan, Sarton, Elise
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560924/
https://ncbi.nlm.nih.gov/pubmed/21508826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e318218a881
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