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Development of targeted therapy for a broad spectrum of solid tumors mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P4 and IGF2-P3 regulatory sequences

Background: The human IGF2-P4 and IGF2-P3 promoters are highly active in a variety of human cancers, while existing at a nearly undetectable level in the surrounding normal tissue. Thus, a double promoter DTA-expressing vector was created, carrying on a single construct two separate genes expressing...

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Библиографические подробности
Главные авторы: Amit, Doron, Tamir, Sagi, Hochberg, Abraham
Формат: Artigo
Язык:Inglês
Опубликовано: e-Century Publishing Corporation 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3560493/
https://ncbi.nlm.nih.gov/pubmed/23386914
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