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Development of targeted therapy for a broad spectrum of cancers (pancreatic cancer, ovarian cancer, glioblastoma and HCC) mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences

BACKGROUND: The human IGF2-P4 and H19 promoters are highly active in a variety of human cancers, while existing at a nearly undetectable level in the surrounding normal tissue. Single promoter vectors expressing diphtheria toxin A-fragment (DTA) under the control regulation of IGF2-P4 or H19 regulat...

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Detalhes bibliográficos
Main Authors: Amit, Doron, Hochberg, Abraham
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443897/
https://ncbi.nlm.nih.gov/pubmed/22993648
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