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Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of IGF2-P3 and IGF2-P4 regulatory sequences

Background: The human IGF2-P3 and IGF2-P4 promoters are highly active in bladder carcinoma, while existing at a nearly undetectable level in the surrounding normal tissue. A double promoter DTA-expressing vector was created, carrying on a single construct two separate genes expressing diphtheria tox...

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Autori principali: Amit, Doron, Tamir, Sagi, Birman, Tatiana, Gofrit, Ofer N, Hochberg, Abraham
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113498/
https://ncbi.nlm.nih.gov/pubmed/21686134
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