Functional Roles of the Non-Catalytic Calcium-Binding Sites in the N-Terminal Domain of Human Peptidylarginine Deiminase 4

This study investigated the functional roles of the N-terminal Ca(2+) ion-binding sites, in terms of enzyme catalysis and stability, of peptidylarginine deiminase 4 (PAD4). Amino acid residues located in the N-terminal Ca(2+)-binding site of PAD4 were mutated to disrupt the binding of Ca(2+) ions. K...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Liu, Yi-Liang, Tsai, I-Chen, Chang, Chia-Wei, Liao, Ya-Fan, Liu, Guang-Yaw, Hung, Hui-Chih
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559651/
https://ncbi.nlm.nih.gov/pubmed/23382808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051660
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