Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway promotes melanoma tumor growth and survival while suppressing autophagy, a catabolic process through which cells collect and recycle cellular components to sustain energy homeostasis in starvation. Conversely...

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Bibliographic Details
Main Authors: Xie, Xiaoqi, White, Eileen P., Mehnert, Janice M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559441/
https://ncbi.nlm.nih.gov/pubmed/23383069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055096
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