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Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma
The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway promotes melanoma tumor growth and survival while suppressing autophagy, a catabolic process through which cells collect and recycle cellular components to sustain energy homeostasis in starvation. Conversely...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3559441/ https://ncbi.nlm.nih.gov/pubmed/23383069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055096 |
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