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Brain Region Specific Pre-Synaptic and Post-Synaptic Degeneration Are Early Components of Neuropathology in Prion Disease

Synaptic abnormalities, one of the key features of prion disease pathogenesis, gives rise to functional deficits and contributes to the devastating clinical outcome. The synaptic compartment is the first to succumb in several neurodegenerative diseases linked with protein misfolding but the mechanis...

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書誌詳細
主要な著者: Šišková, Zuzana, Reynolds, Richard A., O’Connor, Vincent, Perry, V. Hugh
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559345/
https://ncbi.nlm.nih.gov/pubmed/23383030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055004
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