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Brain Region Specific Pre-Synaptic and Post-Synaptic Degeneration Are Early Components of Neuropathology in Prion Disease

Synaptic abnormalities, one of the key features of prion disease pathogenesis, gives rise to functional deficits and contributes to the devastating clinical outcome. The synaptic compartment is the first to succumb in several neurodegenerative diseases linked with protein misfolding but the mechanis...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Šišková, Zuzana, Reynolds, Richard A., O’Connor, Vincent, Perry, V. Hugh
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559345/
https://ncbi.nlm.nih.gov/pubmed/23383030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055004
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