In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation

BACKGROUND: Protein misfolding cyclic amplification (PMCA) is a method that facilitates the detection of prions from many sources of transmissible spongiform encephalopathy (TSE). Sheep scrapie represents a unique diversity of prion disease agents in a range of susceptible PRNP genotypes. In this st...

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Autores principales: Thorne, Leigh, Holder, Thomas, Ramsay, Andrew, Edwards, Jane, Taema, Maged Mohamed, Windl, Otto, Maddison, Ben Charles, Gough, Kevin Christopher, Terry, Linda Ann
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3559253/
https://ncbi.nlm.nih.gov/pubmed/23153009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-6148-8-223
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