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Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model

AFN-1252, a new antimicrobial agent, specifically and potently inhibits fatty acid synthesis in Staphylococcus aureus. We characterized in vivo pharmacokinetic and pharmacodynamic profiles of AFN-1252 administered orally to neutropenic mice inoculated in thighs (∼10(6) CFU) with methicillin-suscepti...

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Sonraí Bibleagrafaíochta
Main Authors: Banevicius, Mary A, Kaplan, Nachum, Hafkin, Barry, Nicolau, David P
Formáid: Artigo
Teanga:Inglês
Foilsithe: Maney Publishing 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558988/
https://ncbi.nlm.nih.gov/pubmed/23433441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1179/1973947812Y.0000000061
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