Mode of Action, In Vitro Activity, and In Vivo Efficacy of AFN-1252, a Selective Antistaphylococcal FabI Inhibitor

The mechanism of action of AFN-1252, a selective inhibitor of Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI), which is involved in fatty acid biosynthesis, was confirmed by using biochemistry, macromolecular synthesis, genetics, and cocrystallization of an AFN-1252–FabI complex. A...

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Detalhes bibliográficos
Main Authors: Kaplan, Nachum, Albert, Monique, Awrey, Donald, Bardouniotis, Elias, Berman, Judd, Clarke, Teresa, Dorsey, Mandy, Hafkin, Barry, Ramnauth, Jaillal, Romanov, Vladimir, Schmid, Molly B., Thalakada, Rosanne, Yethon, Jeremy, Pauls, Henry W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486558/
https://ncbi.nlm.nih.gov/pubmed/22948878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01411-12
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