Drug Metabolism and Transport During Pregnancy: How Does Drug Disposition Change during Pregnancy and What Are the Mechanisms that Cause Such Changes?

There is increasing evidence that pregnancy alters the function of drug-metabolizing enzymes and drug transporters in a gestational-stage and tissue-specific manner. In vivo probe studies have shown that the activity of several hepatic cytochrome P450 enzymes, such as CYP2D6 and CYP3A4, is increased...

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Detaylı Bibliyografya
Asıl Yazarlar: Isoherranen, Nina, Thummel, Kenneth E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2013
Konular:
Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558867/
https://ncbi.nlm.nih.gov/pubmed/23328895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.050245
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