Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes

Little information is available in the literature regarding the expression and activity of transporters in fetal human liver or cultured cells. A synthetic progesterone structural analog, 17α-hydroxyprogesterone caproate (17-OHPC), is used in the prevention of spontaneous abortion in women with a hi...

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Bibliographische Detailangaben
Hauptverfasser: Sharma, Shringi, Ellis, Ewa C. S., Gramignoli, Roberto, Dorko, Kenneth, Tahan, Veysel, Hansel, Marc, Mattison, Donald R., Caritis, Steve N., Hines, Ronald N., Venkataramanan, Raman, Strom, Stephen C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2013
Schlagworte:
Special Section on Drug Metabolizing Enzymes and Transporters in Pregnancy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558857/
https://ncbi.nlm.nih.gov/pubmed/23129211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.044891
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